Pre_GI: SWBIT SVG BLASTN

Query: NC_017223:51180 Bordetella pertussis CS chromosome, complete genome

Lineage: Bordetella pertussis; Bordetella; Alcaligenaceae; Burkholderiales; Proteobacteria; Bacteria

General Information: This group of organisms is capable of invading the respiratory tract of animals and causing severe diseases. They express a number of virulence factors in order to do this including filamentous hemagglutins for attachment, cytotoxins, and proteins that form a type III secretion system for transport of effector molecules into host cells. This organism, which is unable to persist in the environment, is a strict human pathogen that causes whooping cough. Once a common cause of death in children the development of a vaccine has greatly decreased the number of deaths due to Bordetella pertussis. However, this organism infects and estimated 39 million people and kills hundreds of thousands of people each year.

Subject: NC_008785:914411 Burkholderia mallei SAVP1 chromosome II, complete sequence

Lineage: Burkholderia mallei; Burkholderia; Burkholderiaceae; Burkholderiales; Proteobacteria; Bacteria

General Information: This strain is non-virulent. Causes glanders in horses. This organism is rarely associated with human infection, and is more commonly seen in domesticated animals such as horses, donkeys, and mules where it causes glanders, a disease first described by Aristotle. This organism is similar to B. pseudomallei and is differentiated by being nonmotile. The pathogen is host-adapted and is not found in the environment outside of its host. Rapid-onset pneumonia, bacteremia (spread of the organism through the blood), pustules, and death are common outcomes during infection. No vaccine exists for this potentially dangerous organism.