Pre_GI: SWBIT SVG BLASTN

Query: NC_017223:51180 Bordetella pertussis CS chromosome, complete genome

Lineage: Bordetella pertussis; Bordetella; Alcaligenaceae; Burkholderiales; Proteobacteria; Bacteria

General Information: This group of organisms is capable of invading the respiratory tract of animals and causing severe diseases. They express a number of virulence factors in order to do this including filamentous hemagglutins for attachment, cytotoxins, and proteins that form a type III secretion system for transport of effector molecules into host cells. This organism, which is unable to persist in the environment, is a strict human pathogen that causes whooping cough. Once a common cause of death in children the development of a vaccine has greatly decreased the number of deaths due to Bordetella pertussis. However, this organism infects and estimated 39 million people and kills hundreds of thousands of people each year.

Subject: NC_008543:127675 Burkholderia cenocepacia HI2424 chromosome 2, complete sequence

Lineage: Burkholderia cenocepacia; Burkholderia; Burkholderiaceae; Burkholderiales; Proteobacteria; Bacteria

General Information: This organism (HI2424; BCC1) was isolated as part of a study to find this organism in natural environments. Samples taken from fields that were planted with onions in New York in 1999 and 2000 were examined and it was discovered that isolates were the same as ones that can infect CF patients. This species (genomovar III) is part of the Burkholderia cepacia complex, which consists of 9 closely related species, also known as genomovars. These organisms are commonly found in soil and all are opportunistic pathogens espcially in cystic fibrosis patients.