Query: NC_017168:3535786 Yersinia pestis A1122 chromosome, complete genome Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.
- Sequence; - BLASTN hit (Low score = Light, High score = Dark) - hypothetical protein; - cds: hover for description
General Information: Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774 was isolated from the rumen of a sheep. D. desulfuricans reduces sulfate to sulfide found in soil, freshwater, saltwater and the intestinal tract of animals. This organism grows anaerobically and utilizes a wide variety of electron acceptors, including sulfate, sulfur, nitrate, and nitrite, as well as others. The nitrate reduction pathway is not expressed while sulfate is available. Alternatively, the sulfate reduction pathway is constitutively expressed when the cells are growing with nitrate reduction. A number of toxic metals are reduced, including uranium (VI), chromium (VI) and iron (III), making this organism of interest as bioremediator. Metal corrosion, a problem that is partly the result of the collective activity of this bacterium, results in billions of dollars in losses each year to the petroleum industry. This organism is responsible for the production of poisonous hydrogen sulfide gas in marine sediments and in terrestrial environments such as drilling sites for petroleum products.