Pre_GI: SWBIT SVG BLASTN

Query: NC_017160:1507500 Yersinia pestis D182038 chromosome, complete genome

Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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BLASTN Alignment.txt

Subject: NC_008228:2068641 Pseudoalteromonas atlantica T6c, complete genome

Lineage: Pseudoalteromonas atlantica; Pseudoalteromonas; Pseudoalteromonadaceae; Alteromonadales; Proteobacteria; Bacteria

General Information: Isolated from a biofilm from San Diego Bay in California. Marine biofilm bacterium associated with shell disease in shellfish. A common marine bacterium that exists both in the water column, and in biofilms attached to surfaces. This organism produces a well characterized, commercially important agarase. Pseudoalteromonas atlantica has been isolated from lesions on crabs with shell disease. Shell disease is characterized by progressive degradation of the shell, often leading to an infection of the hemolymph (blood) and may be caused by Pseudoalteromonas, Alteromonas, Vibrio, or other marine organisms. In addition to producing extracellular enzymes which attack the shell, Pseudoalteromonas atlantica produces a the lipopolysaccharide which has been shown to be a potential virulence factor in shell disease.