Query: NC_017056:804416 Rickettsia prowazekii str. BuV67-CWPP chromosome, complete genome
Lineage: Rickettsia prowazekii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria
General Information: This species is the causal agent of typhus. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host.
Subject: NC_008601:246583 Francisella tularensis subsp. novicida U112, complete genome
Lineage: Francisella tularensis; Francisella; Francisellaceae; Thiotrichales; Proteobacteria; Bacteria
General Information: Avirulent species. Francisella novicida is closely related to Francisella tularensis, the causative agent for tularemia but is nonvirulent. This organism, however may cause disease in immunocompromised individuals. They do however cause a disease in mice that is very similar to tularemia. This strain was isolated from water in Utah, USA in 1950. Francisella tularensis is a non-motile, aerobic, rod-shaped Gram-negative bacterium and is the causative agent of tularemia.