Pre_GI: SWBIT SVG BLASTN

Query: NC_016948:1796989 Mycobacterium intracellulare MOTT-64 chromosome, complete genome

Lineage: Mycobacterium intracellulare; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, Mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. Mycobacterium intracellulare is a member of the Mycobacterium avium complex (MAC). These organisms cause tuberculosis in birds, and pulmonary and disseminated infections in immunocompromized humans. Mycobacterium intracellulare is also an important contributor to MAC-associated pulmonary infections in immunocompetent patients. Infection results in a characteristic pulmonary disease which requires expensive drug therapy for successful treatment. Mycobacterium intracellulare can also be isolated from the environment and, like other environmental organisms, is able to form and survive in biofilms.

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BLASTN Alignment.txt

Subject: NC_002945:476835 Mycobacterium bovis AF2122/97, complete genome

Lineage: Mycobacterium bovis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection. Causative agent of classic bovine tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of classic bovine tuberculosis, but it can also cause the disease in humans, especially if contaminated milk is consumed without prior pasteurization. The Mycobacterium bovis complex is a diverse group of species, serovars and morphotypes that cause tuberculosis-like diseases in animals and humans. Pasteurization of milk is a major preventitive factor in transmission of bovine tuberculosis to humans. However, spreading the disease through milk and dairy products is still a concern in underdeveloped countries where pasteurization is not practiced.