Query: NC_016943:1560000 Blastococcus saxobsidens DD2, complete genome Lineage: Blastococcus saxobsidens; Blastococcus; Geodermatophilaceae; Actinomycetales; Actinobacteria; Bacteria General Information: Isolated from a sample harvested below the surface of a calcarenite stone from a crumbling wall in Cagliari, Sardinia. Aerobic, chemoorganotrophic, Gram-positive bacterium with a strongly pigmented rudimentary mycelium. It has been isolated from calcarenite walls in Sardinia.
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General Information: This strain is an egg-passaged attentuated avirulent strain that has been used as a live vaccine and was originally isolated from a typhus patient in Madrid. This species is the causal agent of typhus. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host.