Pre_GI: SWBIT SVG BLASTN

Query: NC_016930:943000 Rickettsia philipii str. 364D chromosome, complete genome

Lineage: Rickettsia philipii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: Rickettsiae are obligate intracellular Gram-negative bacteria mostly found in arthropods, some of which cause mild to severe diseases in humans. Spotted fever group rickettsiae (SFGR) cause disease in humans. R .philippi strain 364D, an SFGR, was isolated in 1966 from Dermacentor occidentalis ticks collected in Ventura county, California, and since then 364D has been detected in up to 11% of D. occidentalis from 8 California counties. It has now been recognized as causing eschar-associated illness.

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BLASTN Alignment.txt

Subject: NC_008710:488815 Borrelia turicatae 91E135, complete genome

Lineage: Borrelia turicatae; Borrelia; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria

General Information: This strain was isolated in the USA from the soft tick Ornithodoros turicatae. Borrelia turicatae is the causative agent of tick-borne relapsing fever in the southwestern USA. Ticks become infected with Borrelia while feeding on an infected mammal, usually a rodent or squirrel. Borrelia then multiplies rapidly, causing a generalized infection throughout the tick. While feeding, the tick passes the spirochete into a mammalian host through its infectious saliva. Relapsing fever is characterized by period of chills, fever, headache, and malaise, followed by an asymptomatic, followed by another episode of symptoms. The cycle of relapsing is due to changes in the surface proteins of Borrelia, which allow it to avoid detection and removal by the host immune system. This antigenic variation is the result of homologous recombination of silent proteins into an expressed locus, causing partial or complete replacement of one serotype with another. These plasmids carry genes involved in antigenic variation and pathogenicity.