Pre_GI: SWBIT SVG BLASTN

Query: NC_016930:943000 Rickettsia philipii str. 364D chromosome, complete genome

Lineage: Rickettsia philipii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: Rickettsiae are obligate intracellular Gram-negative bacteria mostly found in arthropods, some of which cause mild to severe diseases in humans. Spotted fever group rickettsiae (SFGR) cause disease in humans. R .philippi strain 364D, an SFGR, was isolated in 1966 from Dermacentor occidentalis ticks collected in Ventura county, California, and since then 364D has been detected in up to 11% of D. occidentalis from 8 California counties. It has now been recognized as causing eschar-associated illness.

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Subject: NC_006511:4119332 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC

Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This serovar has a narrow host range and causes a typhoid-like (paratyphoid fever) illness in humans. It is especially prevalent in southern and eastern Asia, and has been associated with some particularly virulent outbreaks. A number of isolates are increasingly antibiotic resistant. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.