Pre_GI: SWBIT SVG BLASTN

Query: NC_016908:278457 Rickettsia rickettsii str. Colombia chromosome, complete genome

Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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BLASTN Alignment.txt

Subject: NC_007481:3167434 Pseudoalteromonas haloplanktis TAC125 chromosome I, complete

Lineage: Pseudoalteromonas haloplanktis; Pseudoalteromonas; Pseudoalteromonadaceae; Alteromonadales; Proteobacteria; Bacteria

General Information: This strain was isolated from a sample of coastal sea water near a French Antarctic station. This organism is adapted to growth at low temperatures and reactive oxygen species by a number of putative dioxygenases and fatty acid desaturases amongst other proteins. The organism can grow optimally in salt concentrations of 1.5 to 3.5% NaCl.The genome consists of 2 chromosomes, one of which may replicate unidirectionally. Some interesting features of this genome include the lack of the nucleoid-associated gene hns, a lack of genes involved in molybdopterin metabolism, a lack of the cAMP-CAP complex, and a lack of the PEP-dependent PTS system.