Query: NC_016887:1714664 Nocardia cyriacigeorgica GUH-2, complete genome Lineage: Nocardia cyriacigeorgica; Nocardia; Nocardiaceae; Actinomycetales; Actinobacteria; Bacteria General Information: Isolated from a fatal human nocardiosis case at Washington DC, USA in the 1970s. Human pathogen. Nocardia cyriacigeorgica is a filamentous actinobacteria, frequently isolated from diseased human and animal tissues. N. cyriacigeorgica is the most prevalent species responsible for nocardiosis in North America, while placing fourth in France.
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General Information: This symbiotic and thermophilic bacterium was discovered by screening for thermostable tryptanophases in Japanese compost. Cultured growth of this organism requires the presence of another bacterial species, such as a Bacillus or Escherichia coli, which provides diffusable metabolites required for its growth. Pure cultures can be obtained by growing Symbiobacterium thermophilum in a bioreactor, separated from its symbiotic counterpart by a dialysis membrane. Because of its symbiotic nature, it cannot be cultured with conventional methods. Despite a negative reaction for gram stain, this species is placed with the gram-positive bacteria based on 16s phylogenetic analysis.