Query: NC_016818:362548 Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, complete Lineage: Rahnella aquatilis; Rahnella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: Environment: Host; Isolation: drinking water; Temp: Mesophile; Isolation:drinking water. Rahnella aquatilis is a facultatively anaerobic, nitrogen-fixing, gram-negative rod from the Enterobacteriaceae family. It is usually found in fresh water. It is sometimes found in human clinical specimens.
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General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.