Query: NC_016801:394400 Corynebacterium diphtheriae C7 (beta) chromosome, complete genome Lineage: Corynebacterium diphtheriae; Corynebacterium; Corynebacteriaceae; Actinomycetales; Actinobacteria; Bacteria General Information: They may be found as members of the normal microflora of humans, where these bacteria find a suitable niche in virtually every anatomic site. This organism is the best known and most widely studied species of the genus. It is the causal agent of the disease diphtheria, a deadly infectious disease spreading from person to person by respiratory droplets from the throat through coughing and sneezing. In the course of infection, the bacteria invade and colonize tissues of the upper respiratory tract, proliferate and produce exotoxin that inhibits protein synthesis and causes local lesions and systemic degenerative changes in the heart, muscles, peripheral nerves, liver and other vital organs.
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General Information: This strain was derived from a pathogenic strain (8.1b) isolated in 1992 in France that had come from infected twigs derived from the sweet orange strain Valencia in Brazil in the same year. This organism was first identified in 1993 as the causal agent of citrus variegated chlorosis, a disease that affects varieties of sweet oranges. Other strains of this species cause a range of diseases in mulberry, pear, almond, elm, sycamore, oak, maple, pecan and coffee which collectively result in multimillion dollar devastation of economically important plants. Xylella fastidiosa is similar to Xanthomonas campestris pv. campestris in that it produces a wide variety of pathogenic factors for colonization in a host-specific manner including a large number of fimbrial and afimbrial adhesins for attachment. It does not contain a type III secretion system, but possesses genes for a type II secretion system for export of exoenzymes that degrade the plant cell wall and allow the bacterium to colonize the plant xylem.