Query: NC_016148:463840 Thermovirga lienii DSM 17291 chromosome, complete genome Lineage: Thermovirga lienii; Thermovirga; Synergistaceae; Synergistales; Synergistetes; Bacteria General Information: Country: Norway; Environment: Oil fields, Fresh water; Isolation: Production water from an oil well, Norway; Temp: Thermophile; Temp: 58C. Thermovirga lienii was isolated from an oil well in the North Sea.
- Sequence; - BLASTN hit (Low score = Light, High score = Dark) - hypothetical protein; - cds: hover for description
General Information: Isolated from a patient in New York, USA, in 1995. This organism is a tick-borne (Ixodesspp.) obligate intracellular pathogen that infects humans and causes human granulocytic anaplasmosis as well as infecting several other types of animals. This organism produces a number of pathogenic factors that aid virulence. These include specific adhesins for neutrophils, virulence factors that inhibit both phagosome-lysozome fusion and production of reactive oxygen species that would normally kill the bacterium. The bacterium also inhibits programmed cell death of the neutrophil (apoptosis) and induces expression of interleukin-8, which causes neutrophil chemotaxis, thereby increasing the spread of the bacterium throughout the host organism.