Query: NC_016115:62493 Streptomyces flavogriseus ATCC 33331 plasmid pSFLA02, complete Lineage: Streptomyces pratensis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria General Information: Environment: Soil; Isolation: Soil; Temp: Mesophile. The genus Streptomyces consists of soil and water Gram positive filamentous bacteria well known for their ability to produce complex secondary metabolites including many antibiotics. Additionally they undergo complex multicellular development, with spores germinating to form a branched, multinucleoid substrate mycelium, which then produces an aerial mycelium which septates into uninucleoid spores. Streptomyces flavogriseus is an aerobic, Gram-positive bacterium isolated from soil. This organism produces cellulases and xyanases that are able to degrade cellulose and xylan.
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General Information: Soil bacterium producing an antituberculosis agent. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes.