Query: NC_016114:648422 Streptomyces flavogriseus ATCC 33331 chromosome, complete genome Lineage: Streptomyces pratensis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria General Information: Environment: Soil; Isolation: Soil; Temp: Mesophile. The genus Streptomyces consists of soil and water Gram positive filamentous bacteria well known for their ability to produce complex secondary metabolites including many antibiotics. Additionally they undergo complex multicellular development, with spores germinating to form a branched, multinucleoid substrate mycelium, which then produces an aerial mycelium which septates into uninucleoid spores. Streptomyces flavogriseus is an aerobic, Gram-positive bacterium isolated from soil. This organism produces cellulases and xyanases that are able to degrade cellulose and xylan.
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General Information: This strain was isolated from the cerebrospinal fluid a woman who had suffered severe weight loss in Germany. The patient had been treated with antibiotics followed by a year of no treatment prior to the sample being taken. This bacterium is the causative agent of Whipple's disease. Whipple did not associate the disease with any bacterial agent, and it was only in 1961 when bacteria were detected in electron microphotographs of affected tissues that the connection was made. The bacterium cannot be cultured apart from its eukaryotic host, and it grows very slowly (reported duplication time 4-17 days).