Pre_GI: SWBIT SVG BLASTN

Query: NC_015707:1911431 Thermotoga thermarum DSM 5069 chromosome, complete genome

Lineage: Thermotoga thermarum; Thermotoga; Thermotogaceae; Thermotogales; Thermotogae; Bacteria

General Information: Country: Djibouti; Isolation: Continental solfataric spring; Africa; Temp: Hyperthermophile; Temp: 80C. This organism, a member of the Thermotogales, has the characteristic morphology of one or more cells contained in a sheath-like envelope which extends beyond the cell wall. Preliminary sequencing of Thermotogales genomes has identified extensive horizontal gene transfer between these organisms and the Archaea. Thermotoga thermarum does not grow at high salt concentrations (>0.6% NaCL). This organism also produces heat stable enzymes such as endoxylanase, beta xylosidase and alpha arabinofuranosidase which may have commercial uses.

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BLASTN Alignment.txt

Subject: NC_010520:3837378 Clostridium botulinum A3 str. Loch Maree, complete genome

Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.