Query: NC_015707:1911431 Thermotoga thermarum DSM 5069 chromosome, complete genome Lineage: Thermotoga thermarum; Thermotoga; Thermotogaceae; Thermotogales; Thermotogae; Bacteria General Information: Country: Djibouti; Isolation: Continental solfataric spring; Africa; Temp: Hyperthermophile; Temp: 80C. This organism, a member of the Thermotogales, has the characteristic morphology of one or more cells contained in a sheath-like envelope which extends beyond the cell wall. Preliminary sequencing of Thermotogales genomes has identified extensive horizontal gene transfer between these organisms and the Archaea. Thermotoga thermarum does not grow at high salt concentrations (>0.6% NaCL). This organism also produces heat stable enzymes such as endoxylanase, beta xylosidase and alpha arabinofuranosidase which may have commercial uses.
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General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.