Query: NC_014964:557910 Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, complete Lineage: Thermoanaerobacter brockii; Thermoanaerobacter; Thermoanaerobacteraceae; Thermoanaerobacterales; Firmicutes; Bacteria General Information: Isolation: Lake sediment; Africa, Lake Kivu; Temp: Thermophile; Temp: 65C. Thermoanaerobacter brockii is a thermophilic gram positive anaerobe that has been isolated from lake sediment, oil wells and hot springs. This organism ferments hexoses and pyruvate and can reduce thiosulfate to hydrogen sulfide.
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General Information: This strain was isolated in 1985 in California, USA, during an outbreak of listeriosis among patients with AIDS. The strain is of serotype 4b and was isolated from a cheese product that caused the outbreak. This organism, which causes listeriosis, is one of the leading causes of death from food-borne pathogens especially in pregnant women, newborns, the elderly, and immunocompromised individuals. It is found in environments such as decaying vegetable matter, sewage, water, and soil, and it can survive extremes of both temperatures (1-45 degrees C) and salt concentration marking it as an extremely dangerous food-born pathogen, especially on food that is not reheated. This organism is enteroinvasive, and utilizes an actin-based motility system by using a surface protein, ActA, that promotes actin polymerization, to spread intercellularly using the polymerized cytoskeletal protein as a "motor". There are 13 serovars associated with Listeria monocytogenes, and the serovar 4b strains are more commonly associated with invasive disease.