Query: NC_014802:27857 Campylobacter jejuni subsp. jejuni ICDCCJ07001 chromosome, complete Lineage: Campylobacter jejuni; Campylobacter; Campylobacteraceae; Campylobacterales; Proteobacteria; Bacteria General Information: Gram-negative, microaerophilic, flagellate, spiral bacterium, Campylobacter species are the leading cause of food-borne gastroenteritis in developed countries. Infection with C. jejuni is the most frequent antecedent to a form of neuromuscular paralysis known as Guillain-Barre syndrome (GBS). Strain ICDCCJ07001 was isolated following a GBS outbreak in Shuangyang, a town in northern China in 2007, from a severely affected 15 year-old girl GBS patient who had been on a ventilator for 180 days. Her clinical symptoms were motor axonal neuropathy. This organism is the leading cause of bacterial food poisoning (campylobacteriosis) in the world, and is more prevalent than Salmonella enteritis (salmonellosis). Found throughout nature, it can colonize the intestines of both mammals and birds, and transmission to humans occurs via contaminated food products. This organism can invade the epithelial layer by first attaching to epithelial cells, then penetrating through them. Systemic infections can also occur causing more severe illnesses.
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General Information: Temp: Mesophile; Habitat: Host, Root nodule. This biovar is a symbiont of clover plants and is important commercially as it is used in the agricultural industry. Strain WSM1325 is compatible with many perennial clovers of Mediterranean origin used in farming, such as T. pratense, and is therefore one of the most important clover inoculants but is incompatible with American and African perennial clovers, such as those nodulated by the dissimilar strain WSM2304. This organism, like other Rhizobia, establishes a symbiotic relationship with a legume plant, providing nitrogen in exchange for a protected environment. The legume roots secrete flavonoids and isoflavonoids which the bacteria recognize and use to turn on genes involved in root nodulation. Many of the root nodulation genes are involved in synthesis and secretion of a nodule inducing signal, a lipochito-oligosaccharide molecule, which the plant recognizes, triggering nodule formation. The bacterium is endocytosed and exists inside a membrane bound organelle, the symbiosome, and fixes nitrogen for the plant cell while the host cell provides carbon compounds for the bacterium to grow on. The nitrogen fixation is important as it obviates the need for expensive and environmentally damaging fertilizer use.