Query: NC_014733:2851984 Methylovorus sp. MP688 chromosome, complete genome Lineage: Methylovorus; Methylovorus; Methylophilaceae; Methylophilales; Proteobacteria; Bacteria General Information: Methylotrophic bacteria are a group of bacteria which are able to grow aerobically at the expense of methanol as the sole source of carbon and energy, and therefore could serve as biocatalysts for the conversion of methanol to commercially valuable multicarbon compounds like amino acids and cytochromes. Pink-pigmented facultative methylotrophs of the genus Methylovorus are ubiquitous in soil, air and water environments. The MP688 strain was isolated from soil as an PQQ producer.
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General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.