Query: NC_014483:195321 Paenibacillus polymyxa E681 chromosome, complete genome Lineage: Paenibacillus polymyxa; Paenibacillus; Paenibacillaceae; Bacillales; Firmicutes; Bacteria General Information: Paenibacillus polymyxa was isolated from soil and is a member of a group of free-living soil bacteria known to promote plant growth and suppress plant pathogens. Plants treated with Paenibacillus polymyxa have increased resistance to plant pathogens and increased drought resistance. This organism has been shown to produce a number of compounds with antifungal or antibacterial activity.
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General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.