Query: NC_014376:6296 Clostridium saccharolyticum WM1 chromosome, complete genome Lineage: Clostridium saccharolyticum; Clostridium; Lachnospiraceae; Clostridiales; Firmicutes; Bacteria General Information: Country: Canada; Environment: Sludge; Isolation: Sewage sludge in Canada; Temp: Mesophile; Temp: 37C. This organism is able to metablolize a wide range of sugars. This organism was first isolated from a mixed cellulolytic culture started from sewage sludge and relies on the cellulolytic microorganism to provide sugars for growth.
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General Information: This strain was isolated from a patient in 1994. Opportunistic pathogen that causes multiple hospital-acquired infections. This organism is the most medically important organism within the genus Klebsiella. It is an environmental organism found in water, soil, and on the surface of plants. Several strains have been isolated from plant tissues and are nitrogen-fixing endophytes that may be a source of nitrogen for the plant. Other strains can become opportunistic pathogens which infect humans, and typically causes hospital-acquired infections in immunocompromised patients. Major sites of infection include the lungs, where it causes a type of pneumonia, and urinary tract infections. Klebsiella can also enter the bloodstream (bacterimia) and cause sepsis. The pathogen can also infect animals and cause inflammation of the uterus in horses as well as more generalized infections in other mammals. This organism expresses numerous pathogenicity factors, including multiple adhesins, capsular polysaccharide, siderophores, and lipopolysaccharide for the evasion of host defenses. The multiple antibiotic resistance genes carried on the chromosome inhibit efforts to clear the organism from infected patients via antibiotic use.