Pre_GI: SWBIT SVG BLASTN

Query: NC_014335:5165211 Bacillus cereus biovar anthracis str. CI chromosome, complete

Lineage: Bacillus cereus; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain probably caused lethal anthrax in chimpanzee Leo in the rainforest of the Tai National Park, Cote d'Ivoire. It belongs to a collection of genetically closely related bacteria, isolated in 2001 and 2002 from deceased wild chimpanzees living in this rain forest area. An autopsy showed symptoms typical of anthrax, but the bacterium isolated was motile, unlike B.anthracis. This organism is a soil-dwelling opportunistic pathogen that causes food poisoning in infected individuals. The rapid onset is characterized by nausea and vomiting while the late onset is characterized by diarrhea and abdominal pain. The emetic disease is caused by a small stable dodecadepsipeptide cerulide whereas the diarrheal disease is caused by a heat labile enterotoxin. Some strains produce a potent cytotoxin that forms a pore in the membrane of eukaryotic cells and causes necrotic enteritis (death of intestinal epithelial cells) while the unique tripartite membrane lytic toxin hemolysin BL contributes to the diarrheal disease and destructive infections of the eye.

Subject: NC_012962:3864000 Photorhabdus asymbiotica, complete genome

Lineage: Photorhabdus asymbiotica; Photorhabdus; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a North American clinical isolate from human blood. Photorhabdus asymbiota, formerly Xenorhabdus luminescens, has been isolated from human wound and blood infections often in association with spider bites. This species can also be isolated from the entomopathogenic nematode Heterorhabditis indica. Photorhabdus asymbiota is divided into two subspecies, subsp. australis which contains the Australian clinical isolates and subsp. asymbiota which contains the North American isolates. Photorhabdus is currently subdivided into three species, luminescens, temperate and asymbiotica all of which have been isolated as symbionts of heterorhabditid nematodes. This organism is unusual in that it is symbiotic within one insect, and pathogenic in another, the only organism that is known to exhibit this dual phenotype.