Query: NC_014212:319815 Meiothermus silvanus DSM 9946 chromosome, complete genome Lineage: Meiothermus silvanus; Meiothermus; Thermaceae; Thermales; Deinococcus-Thermus; Bacteria General Information: Isolation: Hot spring; Country: Portugal; Temp: Thermophile; Temp: 50C; Habitat: Hot spring. An aerobic, thermophilic, nonmotile Gram-negative bacterium isolated from the hot spring located at the end of a 450 m tunnel and from thermal water piped to a spa at Vizela in northern Portugal. M. silvanus is of special interest as it causes colored biofilms in the paper making industry and may thus be of economic importance as a biofouler. M. silvanus has also been detected in the gut of an invasive wood-boring beetle and in seawater adjacent to a Pacillopora meandrina coral colony at Palmyra Atoll.
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General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.