Query: NC_013961:3269368 Erwinia amylovora, complete genome Lineage: Erwinia amylovora; Erwinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: This bacterium is the causative agent of Fire Blight, a destructive disease of Maloid fruit trees, such as apple and pear. Outbreaks are sporadic in the Northeast, but result in serious damage to roots, blossoms, fruit, and shoots when they occur. The pathogen overwinters in cankers or in smaller limbs. During early spring, in response to both temperature increases and bud development, the bacteria multiplies and may be seen as a yellowish ooze around the perimeter of the canker. Flies and other insects are attracted to the ooze and disperse the inoculum to other trees in the orchard. This species has recently become resistant to streptomycin, an antibiotic traditionally used in its control.
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General Information: This strain was isolated from a patient in 1994. Opportunistic pathogen that causes multiple hospital-acquired infections. This organism is the most medically important organism within the genus Klebsiella. It is an environmental organism found in water, soil, and on the surface of plants. Several strains have been isolated from plant tissues and are nitrogen-fixing endophytes that may be a source of nitrogen for the plant. Other strains can become opportunistic pathogens which infect humans, and typically causes hospital-acquired infections in immunocompromised patients. Major sites of infection include the lungs, where it causes a type of pneumonia, and urinary tract infections. Klebsiella can also enter the bloodstream (bacterimia) and cause sepsis. The pathogen can also infect animals and cause inflammation of the uterus in horses as well as more generalized infections in other mammals. This organism expresses numerous pathogenicity factors, including multiple adhesins, capsular polysaccharide, siderophores, and lipopolysaccharide for the evasion of host defenses. The multiple antibiotic resistance genes carried on the chromosome inhibit efforts to clear the organism from infected patients via antibiotic use.