Query: NC_013855:964000 Azospirillum sp. B510 plasmid pAB510a, complete sequence Lineage: Azospirillum; Azospirillum; Rhodospirillaceae; Rhodospirillales; Proteobacteria; Bacteria General Information: Azospirillum are commonly isolated from the rhizosphere and root surfaces from a wide variety of plants. Azospirillum species are considered to be plant growth promoting organisms, producing plant hormones for cell elongation (auxins), cell division and growth (cytokinins) and stem elongation (gibberellins). These compounds contribute to an enhanced uptake of nutrients and water and thus increased plant growth. Azospirillum sp. B510 was isolated from rice in Japan.
- Sequence; - BLASTN hit (Low score = Light, High score = Dark) - hypothetical protein; - cds: hover for description
General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.