Query: NC_013316:3056925 Clostridium difficile R20291, complete genome Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria General Information: Clostridium difficile R20291 was isolated in Stoke Mandeville Hospital, UK in 2006 and is closely related to the North American hypervirulent BI strains. Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among patients in hospitals worldwide, causing C. difficile infection (CDI). An important nosocomial pathogen, it is frequently associated with antibiotic treatment and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembraneous colitis.
- Sequence; - BLASTN hit (Low score = Light, High score = Dark) - hypothetical protein; - cds: hover for description
General Information: This strain was isolated from a sample of coastal sea water near a French Antarctic station. This organism is adapted to growth at low temperatures and reactive oxygen species by a number of putative dioxygenases and fatty acid desaturases amongst other proteins. The organism can grow optimally in salt concentrations of 1.5 to 3.5% NaCl.The genome consists of 2 chromosomes, one of which may replicate unidirectionally. Some interesting features of this genome include the lack of the nucleoid-associated gene hns, a lack of genes involved in molybdopterin metabolism, a lack of the cAMP-CAP complex, and a lack of the PEP-dependent PTS system.