Query: NC_013316:1 Clostridium difficile R20291, complete genome Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria General Information: Clostridium difficile R20291 was isolated in Stoke Mandeville Hospital, UK in 2006 and is closely related to the North American hypervirulent BI strains. Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among patients in hospitals worldwide, causing C. difficile infection (CDI). An important nosocomial pathogen, it is frequently associated with antibiotic treatment and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembraneous colitis.
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General Information: This strain differs from other isolates based on the combination of its ability to use 2,5-dichlorophenol and its inability to use nitrate as a strong electron acceptor. It can also dechlorinate 2,4-dichlorophenol and 2,4,6-trichlorophenol much faster than other isolates. Can dehalogenate chlorinated phenols. This anaerobic species was originally isolated by enrichment and isolation of single plate-grown colonies, and was the first pure culture of myxobacteria able to grow anaerobically.