Query: NC_013315:1123733 Clostridium difficile CD196 chromosome, complete genome
Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria
General Information: Isolated from a single patient with pseudomembranous colitis in a Paris hospital in 1985. Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among patients in hospitals worldwide, causing C. difficile infection (CDI). An important nosocomial pathogen, it is frequently associated with antibiotic treatment and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembraneous colitis.
Subject: NC_010382:1020516 Lysinibacillus sphaericus C3-41, complete genome
Lineage: Lysinibacillus sphaericus; Lysinibacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria
General Information: Lysinibacillus sphaericus C3-41 was isolated from a mosquito breeding site in China. This organism is highly toxic to Culex species of mosquito. Lysinibacillus sphaericus, formerly Bacillus sphaericus, is a common environmental organism which produces an insecticidal toxin similar to that produced by Bacillus thuringiensis. Lysinibacillus sphaericus produces two proteins during sporulation which accumulate in parasporal crystalline inclusions. These proteins bind in the gastric cavitiy and midgut of the larvae causing disruption of feeding by the infected host and death.