Query: NC_013093:1036772 Actinosynnema mirum DSM 43827, complete genome
Lineage: Actinosynnema mirum; Actinosynnema; Pseudonocardiaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: Isolation: Blade of grass from Raritan River NJ; Country: USA; Temp: Mesophile; Temp: 10-30C; Habitat: Soil. This bacterium produces the antibiotic nocardicin A. Soil dwelling, nonmotile aerobe it has fine hyphae which form aerial and substrate mycelia. Motile spores are borne on synnemata, compact groups of erect hyphae. It produces nocardicin antibiotics and is able to inhibit growth of several Gram-positive bacteria as well as some filamentous fungi and yeasts.
Subject: NC_006142:33268 Rickettsia typhi str. Wilmington, complete genome
Lineage: Rickettsia typhi; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria
General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. Rickettsia typhi causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.