Query: NC_012779:610509 Edwardsiella ictaluri 93-146, complete genome Lineage: Edwardsiella ictaluri; Edwardsiella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria General Information: Edwardsiella ictaluri is the causative agent of enteric septicemia in catfish (ESC), an economically significant disease of farm-raised catfish. The acute form of ESC causes bacterial septicemia (proliferation of bacteria in the blood) which rapidly leads to death. The chronic form of this disease causes a characteristic head lesion, and may also proceed to septicemia and death. Two plasmids, which are consistently present in Edwardsiella ictaluri isolates, have been sequenced. Both plasmids contain genes for the type III secretory system, which is involved in translocating pathogenicity proteins into the eukaryotic cell.
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General Information: First isolated in 1960 in Oxford, England, as an airborne contaminant growing on methylamine. This strain can grow on methylamine or methanol, but not methane. This organism is capable of growth on one-carbon compounds such as methanol. Methanol is oxidized to formaldehyde which is then used metabolically to generate either energy or biomass. These bacteria are commonly found in the environment, especially associated with plants which produce methanol when metabolizing pectin during cell wall synthesis. At least 25 genes are required for this complex process of converting methanol to formaldehyde and this specialized metabolic pathway is of great interest.