Pre_GI: SWBIT SVG BLASTN

Query: NC_012730:652092 Rickettsia peacockii str. Rustic, complete genome

Lineage: Rickettsia peacockii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: Rickettsia peacockii was initially identified in wood ticks from the eastern side of the Bitterroot Valley in Montana. Cases of Rocky Mountain spotted fever in the Bitterroot Valley are associated with exposure to ticks from the western side. Ticks from the east side are primarily infected with R. peacockii which is nonvirulent and may prevent the establishment of pathogenic Rickettsia species in these ticks.

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BLASTN Alignment.txt

Subject: NC_005956:699206 Bartonella henselae str. Houston-1, complete genome

Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.