Query: NC_012668:83641 Vibrio cholerae MJ-1236 chromosome 1, complete sequence Lineage: Vibrio cholerae; Vibrio; Vibrionaceae; Vibrionales; Proteobacteria; Bacteria General Information: Vibrio cholerae MJ-1236 is a toxigenic O1 El Tor Inaba strain from Matlab, Bangladesh, 1994 that represents the "Matlab variant" of El Tor. This genus is abundant in marine or freshwater environments such as estuaries, brackish ponds, or coastal areas; regions that provide an important reservoir for the organism in between outbreaks of the disease. Vibrio can affect shellfish, finfish, and other marine animals and a number of species are pathogenic for humans. Vibrio cholerae can colonize the mucosal surface of the small intestines of humans where it will cause cholera, a severe and sudden onset diarrheal disease. One famous outbreak was traced to a contaminated well in London in 1854 by John Snow, and epidemics, which can occur with extreme rapidity, are often associated with conditions of poor sanitation. The disease has a high lethality if left untreated, and millions have died over the centuries. There have been seven major pandemics between 1817 and today. Six were attributed to the classical biotype, while the 7th, which started in 1961, is associated with the El Tor biotype.
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General Information: Marinomonas MWYL1 was isolated from the root surface of the salt marsh grass Spartina anglica, growing near the North Norfolk, England village of Stiffkey. The genus Marinomonas comprises a widespread group of g -proteobacteria that exist in coastal waters, and which had been earlier been included in the genus Alteromonas. The interest in Marinomonas MWYL 1 was that it could grow on the betaine molecule Dimethylsulphoniopropionate (DMSP) as sole carbon source and, when it did do, it released large amounts of the gas dimethyl sulphide. DMSP is a compatible solute that is used by many marine phytoplankton and seaweed macroalgae as an osmoticum and an anti-stress compound. In addition, a few known land angiosperms make DMSP and these include certain species of Spartina - hence the choice of these plants as a source for DMSP-degrading bacteria. Indeed, others had shown previously that the DMSP-catabolising bacteria isolated from Spartina root surfaces included Marinomonas strains.