Pre_GI: SWBIT SVG BLASTN

Query: NC_012668:2744393 Vibrio cholerae MJ-1236 chromosome 1, complete sequence

Lineage: Vibrio cholerae; Vibrio; Vibrionaceae; Vibrionales; Proteobacteria; Bacteria

General Information: Vibrio cholerae MJ-1236 is a toxigenic O1 El Tor Inaba strain from Matlab, Bangladesh, 1994 that represents the "Matlab variant" of El Tor. This genus is abundant in marine or freshwater environments such as estuaries, brackish ponds, or coastal areas; regions that provide an important reservoir for the organism in between outbreaks of the disease. Vibrio can affect shellfish, finfish, and other marine animals and a number of species are pathogenic for humans. Vibrio cholerae can colonize the mucosal surface of the small intestines of humans where it will cause cholera, a severe and sudden onset diarrheal disease. One famous outbreak was traced to a contaminated well in London in 1854 by John Snow, and epidemics, which can occur with extreme rapidity, are often associated with conditions of poor sanitation. The disease has a high lethality if left untreated, and millions have died over the centuries. There have been seven major pandemics between 1817 and today. Six were attributed to the classical biotype, while the 7th, which started in 1961, is associated with the El Tor biotype.

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BLASTN Alignment.txt

Subject: NC_008228:2068641 Pseudoalteromonas atlantica T6c, complete genome

Lineage: Pseudoalteromonas atlantica; Pseudoalteromonas; Pseudoalteromonadaceae; Alteromonadales; Proteobacteria; Bacteria

General Information: Isolated from a biofilm from San Diego Bay in California. Marine biofilm bacterium associated with shell disease in shellfish. A common marine bacterium that exists both in the water column, and in biofilms attached to surfaces. This organism produces a well characterized, commercially important agarase. Pseudoalteromonas atlantica has been isolated from lesions on crabs with shell disease. Shell disease is characterized by progressive degradation of the shell, often leading to an infection of the hemolymph (blood) and may be caused by Pseudoalteromonas, Alteromonas, Vibrio, or other marine organisms. In addition to producing extracellular enzymes which attack the shell, Pseudoalteromonas atlantica produces a the lipopolysaccharide which has been shown to be a potential virulence factor in shell disease.