Pre_GI: SWBIT SVG BLASTN

Query: NC_012668:442601 Vibrio cholerae MJ-1236 chromosome 1, complete sequence

Lineage: Vibrio cholerae; Vibrio; Vibrionaceae; Vibrionales; Proteobacteria; Bacteria

General Information: Vibrio cholerae MJ-1236 is a toxigenic O1 El Tor Inaba strain from Matlab, Bangladesh, 1994 that represents the "Matlab variant" of El Tor. This genus is abundant in marine or freshwater environments such as estuaries, brackish ponds, or coastal areas; regions that provide an important reservoir for the organism in between outbreaks of the disease. Vibrio can affect shellfish, finfish, and other marine animals and a number of species are pathogenic for humans. Vibrio cholerae can colonize the mucosal surface of the small intestines of humans where it will cause cholera, a severe and sudden onset diarrheal disease. One famous outbreak was traced to a contaminated well in London in 1854 by John Snow, and epidemics, which can occur with extreme rapidity, are often associated with conditions of poor sanitation. The disease has a high lethality if left untreated, and millions have died over the centuries. There have been seven major pandemics between 1817 and today. Six were attributed to the classical biotype, while the 7th, which started in 1961, is associated with the El Tor biotype.

Subject: NC_008011:860000 Lawsonia intracellularis PHE/MN1-00, complete genome

Lineage: Lawsonia intracellularis; Lawsonia; Desulfovibrionaceae; Desulfovibrionales; Proteobacteria; Bacteria

General Information: Lawsonia intracellularis PHE/MN1-00 was isolated from intestinal mucosal lesions in pigs that had proliferative enteropathy (PE). When introduced into health pigs, this organism produced the clinical and histological signs of PE. Causative agent for proliferative enteropathy in swine. This organism causes proliferative enteropathy (ileitis) in swine and other domesticated animals resulting in severe losses each year. This obligate intracellular pathogen infects the mucosa of the lower intestinal tract by initially infecting crypt cells, which are precursors that normally grow and divide in order to replace the epithelial cells. Once infection occurs, the crypt cells are stimulated to grow and divide abnormally, resulting in the proliferative phenotype. In severe cases of the disease the entire bowel can become affected and persist for up to 40 days, greatly affecting the host animal.