Pre_GI: SWBIT SVG BLASTN

Query: NC_012659:5031827 Bacillus anthracis str. A0248, complete genome

Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

- Sequence; - BLASTN hit (Low score = Light, High score = Dark)
- hypothetical protein; - cds: hover for description

BLASTN Alignment.txt

Subject: NC_010382:1020516 Lysinibacillus sphaericus C3-41, complete genome

Lineage: Lysinibacillus sphaericus; Lysinibacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: Lysinibacillus sphaericus C3-41 was isolated from a mosquito breeding site in China. This organism is highly toxic to Culex species of mosquito. Lysinibacillus sphaericus, formerly Bacillus sphaericus, is a common environmental organism which produces an insecticidal toxin similar to that produced by Bacillus thuringiensis. Lysinibacillus sphaericus produces two proteins during sporulation which accumulate in parasporal crystalline inclusions. These proteins bind in the gastric cavitiy and midgut of the larvae causing disruption of feeding by the infected host and death.