Pre_GI: SWBIT SVG BLASTN

Query: NC_012659:3617000 Bacillus anthracis str. A0248, complete genome

Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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BLASTN Alignment.txt

Subject: NC_014774:671695 Candidatus Liberibacter solanacearum CLso-ZC1 chromosome, complete

Lineage: Liberibacter solanacearum; Liberibacter; Rhizobiaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This unculturable bacterium causes Zebra Chip disease of potato. The bacterium was identified in 2008 and named as "Candidatus Liberibacter solanacearum" The disease causes million dollar loss in U.S. potato industry. Liberibacters are phloem-limited bacteria that are spread from infected to healthy plants. The species epithet 'solanacearum' refers to the family of plant hosts found to contain these organisms.