Pre_GI: SWBIT SVG BLASTN

Query: NC_012563:4101000 Clostridium botulinum A2 str. Kyoto, complete genome

Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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BLASTN Alignment.txt

Subject: NC_006582:883922 Bacillus clausii KSM-K16, complete genome

Lineage: Bacillus clausii; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: Alkaliphilic strain of was isolated from soil. Alkaline-tolerant bacterium. Bacillus clausii is able to tolerate high pH levels and produces alkaline-tolerant enzymes particularly alkaline proteases. B. clausii have been isolated from soil and water. This organism has also been reported to have a beneficial effect in the human gut and is being considered for use as a probiotic.