Query: NC_012472:5239944 Bacillus cereus 03BB102, complete genome Lineage: Bacillus cereus; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria General Information: Bacillus cereus 03BB102 was cultured from the blood of a 39 year old San Antonio, Texas welder who died as a result of a severe pneumonia thought to be caused by this microbe. Unlike B. anthracis, the isolate is hemolytic, motile and resistant to gamma phage. However, it is positive for a DFA-based cell wall test for B. anthracis, and it has all or most of the pXO1 pathogenicity island sequences including the sequences for pag, cya and lef. This organism is a soil-dwelling opportunistic pathogen that causes food poisoning in infected individuals. The rapid onset is characterized by nausea and vomiting while the late onset is characterized by diarrhea and abdominal pain. The emetic disease is caused by a small stable dodecadepsipeptide cerulide whereas the diarrheal disease is caused by a heat labile enterotoxin. Some strains produce a potent cytotoxin that forms a pore in the membrane of eukaryotic cells and causes necrotic enteritis (death of intestinal epithelial cells) while the unique tripartite membrane lytic toxin hemolysin BL contributes to the diarrheal disease and destructive infections of the eye.
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General Information: Staphylococcus haemolyticus JCSC1435 was isolated from a Japanese inpatient at Juntendo Hospital, Tokyo, in 2000. This strain is a highly resistant strain which has been shown to generate spontaneous antibiotic sensitive mutants. Causes opportunistic infections in humans. Staphylcocci are generally found inhabiting the skin and mucous membranes of mammals and birds. Some members of this genus can be found as human commensals and these are generally believed to have the greatest pathogenic potential in opportunistic infections. Staphylococcus haemolyticus was originally isolated from human skin and traditionally considered to be a nonpathogenic commensal. Recently this organism has been recognized as a pathogen in animals and humans. It is known to be involved in opportunistic infections associated with the implantation of foreign bodies, paticularly in those with compromised immune systems. Resistance to multiple antibiotics has been observed in clinical isolates and it is possible S. haemolyticus could serve a donor or resistance genes to other more virulent staphlococci.