Pre_GI: SWBIT SVG BLASTN

Query: NC_011896:363448 Mycobacterium leprae Br4923, complete genome

Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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BLASTN Alignment.txt

Subject: NC_012590:2501593 Corynebacterium aurimucosum ATCC 700975, complete genome

Lineage: Corynebacterium aurimucosum; Corynebacterium; Corynebacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Corynebacterium aurimucosum ATCC 700975 (DSM 44827) was isolated from the human female urogenital tract. Corynebacterium aurimucosum has been isolated from a number of clinical samples including blood and infected bone, however it is not known what role this organism may have in the development of disease. This organism is also isolated from healthy female urogenital tract samples and is considered part of the normal microbial community.