Pre_GI: SWBIT SVG BLASTN

Query: NC_011896:3040500 Mycobacterium leprae Br4923, complete genome

Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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Subject: NC_014165:3559305 Thermobispora bispora DSM 43833 chromosome, complete genome

Lineage: Thermobispora bispora; Thermobispora; Pseudonocardiaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Isolation: Decaying manure; Temp: Thermophile; Temp: 55 - 65C; Isolation: decaying manure. Thermobispora bispora is a thermophilic actinomycete which is able to grow at 65 degrees C and not at 35 degrees C. This organism forms aerial mycelia which contain longitudinal pairs of spores.