Query: NC_011891:2088134 Anaeromyxobacter dehalogenans 2CP-1, complete genome Lineage: Anaeromyxobacter dehalogenans; Anaeromyxobacter; Myxococcaceae; Myxococcales; Proteobacteria; Bacteria General Information: This strain (2CP-1; ATCC BAA-258) is the type strain for the species and was isolated from stream sediment near Lansing, Mich., USA. This anaerobic species was originally isolated by enrichment and isolation of single plate-grown colonies, and was the first pure culture of myxobacteria able to grow anaerobically. The unique physiological characteristics of this organism include the ability to use ortho-substituted mono- and dichlorinated phenols, nitrate, H2 and fumarate as terminal electron acceptors.
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General Information: Sorangium cellulosum 'So ce 56' produces a large number of bioactive compounds, such as, the antifungal soraphen and the anticancer agent epothilone. This organism, like other myxobacteria, undergoes a complex development and differentiation pathway. When cell density increases, the organism switches to "social motility" where aggregates of cells can gather together into masses termed fruiting bodies that may consist of up to 100 000 cells. The motility system is not dependent on flagella like most bacteria, but instead relies on twitching pili: short extracellular appendages that may function analogously to oars in a rowboat. The myxobacteria have proved to be a rich source of novel natural products. Sorangium cellulosum produces a number of antibacterial, antifungal and cytotoxic substances which are being studies for therapeutic applications.