Query: NC_011883:2031222 Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774, Lineage: Desulfovibrio desulfuricans; Desulfovibrio; Desulfovibrionaceae; Desulfovibrionales; Proteobacteria; Bacteria General Information: Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774 was isolated from the rumen of a sheep. D. desulfuricans reduces sulfate to sulfide found in soil, freshwater, saltwater and the intestinal tract of animals. This organism grows anaerobically and utilizes a wide variety of electron acceptors, including sulfate, sulfur, nitrate, and nitrite, as well as others. The nitrate reduction pathway is not expressed while sulfate is available. Alternatively, the sulfate reduction pathway is constitutively expressed when the cells are growing with nitrate reduction. A number of toxic metals are reduced, including uranium (VI), chromium (VI) and iron (III), making this organism of interest as bioremediator. Metal corrosion, a problem that is partly the result of the collective activity of this bacterium, results in billions of dollars in losses each year to the petroleum industry. This organism is responsible for the production of poisonous hydrogen sulfide gas in marine sediments and in terrestrial environments such as drilling sites for petroleum products.
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General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.