Query: NC_011295:1120584 Coprothermobacter proteolyticus DSM 5265, complete genome Lineage: Coprothermobacter proteolyticus; Coprothermobacter; Thermodesulfobiaceae; Thermoanaerobacterales; Firmicutes; Bacteria General Information: This organism was isolated from a thermophilic digestor that was fermenting tannery wastes and cattle manure. Coprothermobacter proteolyticus is a nonmotile, non-spore-forming, rod-shaped, Gram-negative anaerobic bacterium. This organism was originally classified as Thermobacteroides proteolyticus and subsequently assigned to the new genus of Coprothermobacter.
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General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.