Pre_GI: SWBIT SVG BLASTN

Query: NC_011283:1307173 Klebsiella pneumoniae 342 chromosome, complete genome

Lineage: Klebsiella pneumoniae; Klebsiella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Klebsiella pneumoniae 342 was isolated from the stem tissue of Zea mays. This strain fixes atmospheric nitrogen and may be able to provide nitrogen, in the form of ammonia, to plant cells. This organism is the most medically important organism within the genus Klebsiella. It is an environmental organism found in water, soil, and on the surface of plants. Several strains have been isolated from plant tissues and are nitrogen-fixing endophytes that may be a source of nitrogen for the plant. Other strains can become opportunistic pathogens which infect humans, and typically causes hospital-acquired infections in immunocompromised patients. Major sites of infection include the lungs, where it causes a type of pneumonia, and urinary tract infections. Klebsiella can also enter the bloodstream (bacterimia) and cause sepsis. The pathogen can also infect animals and cause inflammation of the uterus in horses as well as more generalized infections in other mammals. This organism expresses numerous pathogenicity factors, including multiple adhesins, capsular polysaccharide, siderophores, and lipopolysaccharide for the evasion of host defenses. The multiple antibiotic resistance genes carried on the chromosome inhibit efforts to clear the organism from infected patients via antibiotic use.

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BLASTN Alignment.txt

Subject: NC_002940:1234410 Haemophilus ducreyi 35000HP, complete genome

Lineage: Haemophilus ducreyi; Haemophilus; Pasteurellaceae; Pasteurellales; Proteobacteria; Bacteria

General Information: This strain is a human passage derivative of Haemophilus ducreyi strain 35000 that is serum-resistant. Causative agent of chancroid. A group of organisms that are either obligate parasites or commensal organisms found in animal mucous membranes. Almost all species require the presence of important growth factors found in the blood of their hosts, including either X factor (protoporphyrin IX or heme) or V factor (nicotinamide adenine dinucleotide (NAD or NADP)). This organism is an obligate human pathogen that causes the sexually transmitted disease chancroid (ulcer of the genital region) and it enhances the transmission of HIV (which enhances Haemophilus ducreyi transmission in turn). This organism is an apparent extracellular pathogen that resists phagocytosis. Some of the virulence factors include an outer membrane serum resistance protein, as well as two toxins, cytolethal distending toxin (CDT) and hemolysin, both of which contribute to tissue destruction.