Pre_GI: SWBIT SVG BLASTN

Query: NC_011274:4385039 Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91

Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Salmonella gallinarum is the causative agent of Fowl typhoid, a severe systemic disease of poultry. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

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BLASTN Alignment.txt

Subject: NC_010554:2872000 Proteus mirabilis HI4320, complete genome

Lineage: Proteus mirabilis; Proteus; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Proteus mirabilis is a tetracycline resistant human urinary tract isolate. This bacterium is part of the normal gut flora of a healthy individual, but is also an opportunistic pathogen. Flagellar movement allows this organism to travel through the urinary tract into the bladder and kidney where it may cause infection or stones. Cell death is caused by hemolysin, a pore-forming toxin which disrupts osmotic balance across the host cell membrane. This species is inherently resistant to nitrofuran and tetracycline, and some strains have recently become resistant to ampicillin and trimethoprin.