Pre_GI: SWBIT SVG BLASTN

Query: NC_011147:529458 Salmonella enterica subsp. enterica serovar Paratyphi A str

Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a clinical isolate collected from a child with paratyphoid fever in Karachi, Pakistan, 2004. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

Subject: AC_000091:2462461 Escherichia coli W3110 DNA, complete genome

Lineage: Escherichia coli; Escherichia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism was named for its discoverer, Theodore Escherich, and is one of the premier model organisms used in the study of bacterial genetics, physiology, and biochemistry. This enteric organism is typically present in the lower intestine of humans, where it is the dominant facultative anaerobe present, but it is only one minor constituent of the complete intestinal microflora. E. coli, is capable of causing various diseases in its host, especially when they acquire virulence traits. E. coli can cause urinary tract infections, neonatal meningitis, and many different intestinal diseases, usually by attaching to the host cell and introducing toxins that disrupt normal cellular processes.