Pre_GI: SWBIT SVG BLASTN

Query: NC_011035:566980 Neisseria gonorrhoeae NCCP11945 chromosome, complete genome

Lineage: Neisseria gonorrhoeae; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: Neisseria gonorrhoeae NCCP11945 was isolated in 2002 from a vaginal smear of a Korean patient. This is a multidrug-resistant strain. One of two pathogenic Neisseria, this species causes the sexually transmitted disease (STD) gonorrhea, which is the leading reportable STD in adults in the USA. This human-specific organism colonizes and invades the mucosal surface of the urogenital epithelium, crosses the epithelial barrier, and ends up multiplying on the basement membrane. Pathogenic functions include the antigenically variable type IV pilus and the opacity (Opa) proteins. The Opa proteins are responsible for the opaque colony phenotype due to the tight junctions between adjacent Neisseria, and are also responsible for tight adherence to host cells. This organism, like Neisseria meningitidis, is also naturally competent for DNA uptake.

Subject: NC_012779:2664849 Edwardsiella ictaluri 93-146, complete genome

Lineage: Edwardsiella ictaluri; Edwardsiella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Edwardsiella ictaluri is the causative agent of enteric septicemia in catfish (ESC), an economically significant disease of farm-raised catfish. The acute form of ESC causes bacterial septicemia (proliferation of bacteria in the blood) which rapidly leads to death. The chronic form of this disease causes a characteristic head lesion, and may also proceed to septicemia and death. Two plasmids, which are consistently present in Edwardsiella ictaluri isolates, have been sequenced. Both plasmids contain genes for the type III secretory system, which is involved in translocating pathogenicity proteins into the eukaryotic cell.