Query: NC_010725:1003760 Methylobacterium populi BJ001, complete genome Lineage: Methylobacterium populi; Methylobacterium; Methylobacteriaceae; Rhizobiales; Proteobacteria; Bacteria General Information: This species was isolated from tissue cultures of Populus, the Poplar tree. Colonies are pink to red, and the red pigment is water insoluble. Species of the genus Methylobacterium are strictly aerobic, facultatively methylotrophic, Gram-negative, rod-shaped bacteria that are able to grow on one-carbon compounds (e.g. methanol or methylamine), as well as on a variety of C2, C3 and C4 substrates. Only the type species, Methylobacterium organophilum, has been shown to use methane as the sole source of carbon and energy. Members of the genus are distributed in a wide variety of natural and man-made environments, including soil, air, dust, fresh- and marine water and sediments, water supplies, bathrooms, air-conditioning systems and masonry, and some are opportunistic human pathogens.
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General Information: This strain was isolated from human gingiva. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.